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China Primer: Illicit Fentanyl and China's Role


For over a decade, the synthetic opioid fentanyl and
fentanyl-related substances have been key drivers of the
U.S. opioid crisis. Countering the illicit trafficking of
fentanyl and the precursor chemicals (precursors) used to
make  it has been a U.S. priority. In 2017, the U.S.
Department of State first identified the People's Republic of
China (PRC, or China) as the main source of U.S.-bound
fentanyl and fentanyl precursors. Since the PRC imposed
domestic controls on fentanyl-related substances in 2019,
which curtailed almost all direct shipments of fentanyl from
China to the United States, many U.S. policymakers have
shifted focus. A chief concern of U.S. policymakers today
is the role of China-the global leader in chemical sales-
as the primary source of precursors used by transnational
criminal organizations (TCOs) to synthesize fentanyl and
its analogues in third countries (chiefly Mexico). Congress
has sought to address China's shifting role in the illicit drug
trade, including through provisions in the BUST Fentanyl
Act in the National Defense Authorization Act for FY2026.

  ackground
Fentanyl is a potent synthetic opioid that has been used
medically as a painkiller and an anesthetic since it was first
synthesized in 1959. Due to fentanyl's potential for abuse
and addiction, the United Nations (UN) placed it under
international control in 1964. Domestically, fentanyl is
regulated by the U.S. Drug Enforcement Administration
(DEA), pursuant to the Comprehensive Drug Abuse
Prevention and Control Act of 1970, as amended (21 U.S.C.
§§801 et seq.). The U.S. Centers for Disease Control and
Prevention estimate that synthetic opioids (primarily
fentanyl-related substances) resulted in about 37,393 U.S.
overdose deaths in 2025-a decrease of 52% from the peak
of 77,695 deaths from July 2022-June 2023.
As of April 2026, the International Narcotics Control Board
(INCB)-an   independent expert body that monitors
governments' compliance with UN  drug control
conventions-reported  the existence of 183 fentanyl-related
substances with no known legitimate use. The UN Office
on Drugs and Crime estimates that laboratories could
potentially synthesize thousands of fentanyl-related
substances. More than 30 fentanyl-related substances,
including precursors, are controlled (scheduled)
internationally pursuant to the UN Single Convention on
Narcotic Drugs of 1961, as amended, and the UN
Convention Against Illicit Traffic in Narcotic Drugs and
Psychotropic Substances of 1988. UN member states began
scheduling fentanyl precursors for international control in
2017. As of May 2026, the INCB had scheduled seven
fentanyl precursors for international control.
Sources and Traffickin Pathways
According to the DEA, fentanyl sourced from China
accounted for 97% of high-purity fentanyl seized from
shipments to the United States in 2016 and 2017. In 2019,


Updated June 1, 2026


in response to U.S. concerns expressed by the first Trump
Administration, the PRC government controlled fentanyl
substances as a class, leading to a major change in
trafficking patterns. According to the Department of State's
March  2025 International Narcotics Control Strategy
Report (INCSR), almost no fentanyl or fentanyl analogues
have been detected directly entering the United States from
[China] since the PRC implemented controls over fentanyl-
related substances as a class in 2019. (The report notes that
production of U.S.-bound illicit fentanyl and analogues is
now  concentrated in Mexico.)

China and India are the primary source countries for illicit
fentanyl precursor chemicals and pill pressing equipment,
according to the U.S. intelligence community's March 2026
Annual Threat Assessment. China's massive chemical and
pharmaceutical industries make the PRC a primary supplier
not only of precursors for fentanyl, but also for illicit drugs
including methamphetamine, ketamine, and nitazenes.
Because of the PRC's role as a supplier of precursors, the
President has designated China a major illicit drug
producing or drug transit country since 2023, following
Congress' 2022 amendment  (P.L. 117-263) of the definition
to include synthetic drugs and their precursors.

U.S.   Executive Branch Actions
Successive administrations have acted to address China's
role in the trafficking of fentanyl and its precursors. The
United States has sanctioned PRC citizens and PRC-based
companies. Over the past decade, the executive branch also
has indicted dozens of PRC citizens and PRC-based
companies for their alleged involvement in the trafficking
of synthetic drugs, precursor chemicals, and pill making
equipment, and related money laundering. In December
2025, the second Trump Administration, through Executive
Order (E.O.) 14367, designated illicit fentanyl and its core
precursor chemicals as Weapons of Mass Destruction.

The second Trump  Administration has sought to address
China's role in the U.S. opioid epidemic in part through
trade-related actions. On February 1, 2025, the White
House issued E.O. 14195, which expanded the national
emergency  the President declared in January 2025
(Proclamation 10886) to cover the PRC government's
alleged failures to interdict suppliers of precursors, money
launderers, and other actors related to TCOs. The order
subsequently imposed an additional 10% tariff on PRC
products pursuant to authorities including those under the
International Emergency Economic Powers Act (IEEPA).
In February 2026, after various changes to tariff rates by the
Administration in 2025, the Supreme Court invalidated
tariffs imposed under IEEPA authorities, including those on
PRC  products. In 2025, the President also directed duty-free
de minimis treatment to be suspended for low-value imports
from China (premised on the alleged use of such shipments