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              Congressional                                            ____
           **Research Service
 ~~~ i~~nforming the legislative debate since 1914 ___________________




 HALT Fentanyl Act Permanently Controls

 Fentanyl-Related Substances



July  29, 2025

On July 17, 2025, President Trump signed into law the Halt All Lethal Trafficking of Fentanyl Act (HALT
Fentanyl Act). Among other things, the HALT Fentanyl Act permanently placed certainfentanyl-related
substances (FRS)-a class of compounds chemically related to the powerful synthetic opioid fentanyl-
in Schedule I of the Controlled Substances Act (CSA). Before the enactment of the HALT Fentanyl Act,
FRS had been subject to temporary CSA control since February 2018.
This Legal Sidebar provides an overview of FRS control and the HALT Fentanyl Act, then discusses
selected considerations for Congress related to the regulation of FRS and other opioids.

The   CSA   and  Controlled Substance Regulation

The CSA  regulates drugs and other substances-whether medical or recreational, legally or illicitly
distributed-that pose a risk of abuse and dependence. The Drug Enforcement Administration (DEA), an
agency within the Department of Justice, is the federal agency primarily responsible for implementing
and enforcing the CSA.
Substances become subject to the CSA through placement in one of five lists, known as Schedules I
through V. Controlled substances in Schedule I are subject to the most stringent controls, as they are
deemed to have a high potential for abuse and no currently accepted medical use. It is legal to produce,
dispense, and possess Schedule I substances only in the context of federally approved scientific studies.
Substances in Schedules II through V have accepted medical uses and have been deemed to pose
progressively lower risks of abuse and dependence. Those substances may be used for medical purposes,
generally by prescription. Anybody who handles a controlled substance, other than an ultimate user, must
register with DEA and comply with CSA registration requirements, which include security and reporting
obligations.
Either Congress or the DEA administrator can place a substance in a CSA schedule, move a substance to a
different schedule, or remove a substance from the schedules. Congress can take those scheduling actions
by enacting legislation. DEA, for its part, may make permanent scheduling decisions through a formal
rulemaking process and can also temporarily place substances in Schedule I on an emergency basis.


                                                               Congressional Research Service
                                                               https://crsreports.congress.gov
                                                                                   LSB11343

CRS Legal Sidebar
Prepared for Members and
Committees of Congress