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              Congressional
           ~Research Service
               Informing the legisIative debate since 1914___________________




Advances in DNA Analysis: Fourth

Amendment Implications



July  11, 2025

Law  enforcement has used deoxyribonucleic acid, or DNA, as an investigative tool for decades. DNA is
the fundamental building block for an individual's entire genetic makeup and may be extracted from
many  sources, such as hair, bone, teeth, saliva, and blood. Investigators routinely compare DNA from
known  suspects with DNA recovered from crime scenes or victims, or look for matches between crime
scene DNA  and law enforcement databases of offender DNA profiles. Federal courts, including the
Supreme Court, have generally upheld statutory DNA identification regimes against Fourth Amendment
challenges.
This Sidebar provides legal background on DNA identification and the Fourth Amendment, with
particular emphasis on the 2013 Supreme Court case Maryland v. King. It then examines selected Fourth
Amendment  issues, including lingering questions from King that could potentially be relevant to a newer
DNA  investigative technique, which the Department of Justice (DOJ) has calledforensic genetic
genealogical DNA analysis and searching (sometimes described as investigative genetic genealogy or
forensic genetic genealogy). The Sidebar concludes with congressional considerations.

Maryland v. King: the Fourth Amendment and DNA Identification

The Fourth Amendment imposes limits on searches and seizures by the government. Courts have
determined that a Fourth Amendment search occurs if the Government obtains information by physically
intruding on a constitutionally protected area or when the government violates a subjective expectation
of privacy that society recognizes as reasonable. If a law enforcement activity qualifies as a search or
seizure, then the Fourth Amendment requires that it must be reasonable, which ordinarily means that the
search or seizure must be conducted pursuant to a warrant supported by probable cause, with some
exceptions.







                                                              Congressional Research Service
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 CRS Legal Sidebar
 Prepared for Members and
 Committees of Congress